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Mind & Body Solution for PMS

About Dr. Jarret Morrow:

Dr. Jarret Morrow, MD is the President & Chief Science Officer of University Health Industries, Inc. Dr. Morrow received his Doctor of Medicine at the University of Alberta in June 2001 and before that, received his Bachelor of Science with Specialization in Pharmacology with distinction from the University of Alberta, in June 1997. Dr. Morrow has a distinguished presenter at numerous scientific and worldwide medical conferences have been, usually with different areas of psychiatry, including anxiety disorders and the physical effects of mental stress, and also the cooperation of numerous medical research publications has written widely on similar themes. Dr. Morrow is the inventor of two patent-pending dietary Formulations ( food updates ).

University Health Industries Disclaimer:

The information on this site is so provided, on knowledge of your general only. This Information is not a substitute for professional medical advice or treatment for specific diseases. Let us always the advice of your physician or other qualified health provider with issues in respect of a particular disease.
Never disregard medical advice or delay in access to medical advice or treatment because of something you have read, ™ on this website or the University Health Industries Web site.

Part 1: About PMS

1. What are PMS and PMDD?
2. What causes PMS?
3. What are the symptoms of PMS?
4. What are the risks of PMS and PMDD?
5. How can I tell if I have PMS?
6. What can I do to manage my symptoms?
7. What medical treatments are available?
8. How effective are selective serotonin reuptake inhibitors inhibitors (SSRIs) for treatment of PMS?
   What is the efficacy of the gonadotropin-releasing hormone analogues (GnRHa) therapy in the treatment of PMS?
9. Bright light therapy is effective in the treatment of depression associated with premenstrual dysphoric disorder?

Part 2: About Zenstral

1. What is PMS Zenstral ™?
2. Who should Zenstral PMS ™?
3. What are the ingredients?
4. How does Zenstral PMS ™?
5. What is Evidence Based Medicine?
6. What is a meta-analysis?
7. What scientific evidence was used in the formulation Zenstral PMS ™?
8. Who should not Zenstral PMS ™?
9. How much should I take?
10. When will it start to work?
11. What are the possible side effects?
12. What is the NPA TruLabel Program?
13. What is your warranty?
14. Who University Health Industries, Inc. (UHI)?
15. What other nutraceuticals are available from UHI?

Part 1: About PMS

Understanding of PMS is one of the most important things you can do those at Manage your symptoms. This booklet provides Jarret D. Morrow, MD, Chief Scientific Officer and President of University Health Industries, the known facts on PMS, an overview of treatment options and the latest independent research, that the use of Zenstral PMS ™ to alleviate PMS and PMDD supported.

What are PMS and PMDD?

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), a severe form of PMS, are both very frequent and potentially debilitating conditions suffered by many women. Hormonal changes after ovulation trigger a group of disruptive symptoms that about 14 days to appear before your time. PMS and PMDD affect require an estimated 40 million women in the United States with more than five million medical treatment.

What causes PMS?

Although the exact cause of PMS is not completely understood, it seems that the hormones progesterone, Estrogen and testosterone are involved, along with changes in the level of the brain chemical serotonin. Nutrient deficiency in magnesium or vitamin B6, hormonal changes, Neurotransmitter activity, diet and stress are all implicated in the etiology of PMS.1, 2

What are the symptoms of PMS?

Most women feel some discomfort before their time. But if you have PMS, you may feel so anxious, depressed or uncomfortable that you are not home or to cope at work. Common symptoms of PMS are:

Physical symptoms / mental symptoms

• Breast Tenderness (mastodynia)
• Irritability
• Cramping
• Tantrums
• Swollen hands or feet
• Low self-esteem
• Headache
• Fear
• Weight gain
• Confusion
• Bloated abdomen
• Difficulty concentrating
• Constipation
• Mood swings
• Joint pain
• Crying spells
• Fatigue
• Decreased libido
• Acne
• Depression

Symptoms usually stop or taper off soon after the period begins, and you can be symptom-free until about two weeks before your next period.

What are the risks of the PMD and PMDD?

PMS and PMDD are not mere inconveniences. These conditions may adversely affect a woman's personal, professional and financial success. Women suffer from PMS have a increased risk of depression, absenteeism from work, strained relationships, reduced productivity, deterioration of medical conditions such as epilepsy, asthma, Fibromyalgia, multiple sclerosis or migraine during certain phases of the menstrual cycle.

How can I tell if I have PMS?

According to the American College of Obstetricians and Gynecologists (ACOG), you may have, if PMS

• Your PMS symptoms occur only during the last two weeks of the cycle.
• the symptoms are sufficiently troublesome to interfere with your life.
• other diseases that mistaken for PMS can be excluded.

If you suspect you have PMS, ACOG recommends that keeps a daily log of your symptoms for two or assist in three consecutive months of diagnosis. It is important that you speak with your doctor to confirm your diagnosis and exclusion of other possible causes of your Symptoms such as depression, migraine, seizure disorders, irritable bowel syndrome, chronic fatigue syndrome, or allergies.

What can I do about my manage PMS symptoms?

Women can often manage the symptoms of premenstrual syndrome by changes in the way they eat, exercise and Approach their daily lives. How to reduce your discomfort, try as many of the implementation of the following suggestions, as you can.

Nutrition Notes for the control of PMS

• Eating frequent meals to reduce smaller, more Flatulence and bloating.
• Eat complex carbohydrates such as wholemeal bread, pasta and cereals.
• Cut back on sugar and fat in your diet.
• Avoid salt for the last few days before the period to reduce bloating and Fluid retention.
• Avoid caffeine to feel less tense and irritable.
• Avoid alcoholic beverages. The consumption of alcohol before your time, you may feel depressed themselves.
• Choose foods rich in calcium.
• Increase consumption of dietary fiber.

Lifestyle tips for controlling PMS

• Get aerobic exercise. Regular daily exercise will help improve your overall health and can make symptoms as alleviating fatigue and depressive mood.
• Ensuring adequate sleep about eight hours per night.
• Try You, stressful events period schedule for the week after.
• Keep a regular schedule of meals, bedtime, and exercise.
• deep breathing exercises to reduce practice headaches, anxiety or sleep disorders to help.
• Avoid smoking cigarettes.

What are medical treatments for PMS and PMDD?

There are four types of prescription drugs for PMS / PMDD used:

1. Antidepressants that act on serotonin, including fluoxetine, sertraline, and FDA has recently paroxetine.The makers of antidepressants pay more black box warnings to that patient on this Medications should be closely for clinical worsening, suicidality, or unusual changes in behavior are observed. "
2. Agents, which suppress ovulation, such as danazol, estradiol transdermal patches and some oral contraceptives. These drugs carry risks for serious side effects and can be very expensive be.
3. Other psychotropic drugs to reduce anxiety, such as alprazolam and other benzodiazepines anxiolytic. Since Alprazolam has a very short half-life, there is a risk of addiction for patients who are started on this medication.
4. Spironolactone, a diuretic that is only on prescription. It has been proven to reduce the premenstrual fluid retention effective, but not the other symptoms of PMS.

How effective are selective serotonin reuptake inhibitors (SSRI) for the treatment of PMS?

SSRI's are used in a class of drugs in the treatment of depression, anxiety and personality disorders. Patients can experience many side effects from use of these drugs, including weight changes, increased anxiety, suicidal thoughts and sexual dysfunction. A study published in the Cochrane Database concluded that there is very good evidence on the use of selective serotonin reuptake inhibitors in the management support of severe PMS. However, withdrawals were due to adverse events occur 2.5 times more frequently in the treatment group than in the placebo group.3

What is the effectiveness to treat the use of gonadotropin-releasing hormone analogues (GnRHa) to PMS?

GnRH analogues working month to stop bleeding by decreasing estrogen production. A recent Meta-analysis in the British Journal of Obstetrics and Gynecology published conclusion that GnRHa treatment, an effective option in the management of patients unfortunately seems to be PMS.4 who may experience these analogues more serious side effects, including menopausal symptoms such as hot flashes, mood swings, vaginal dryness and elevated LDL-cholesterol and bone loss.

Light therapy is effective in the treatment of depression associated with premenstrual dysphoric disorder?

Light therapy consists of exposure to full spectrum light for a predetermined period of time. A recent meta-analysis of light therapy in the American Journal of Obstetrics published and Gynecology concluded that "the current evidence neither enthusiastic nor convinced dissemination justifies rejection of this form of therapy." 5 essentially this means that more research is needed to investigate the potential benefits of this treatment for PMS.

Part 2: About Zenstral PMS ™

From University Health Industries

Zenstral of PMS Industries (OTC: UVHI) "> University Health Industries

Testimonial:

"I want to thank you for all your help. I have the worst possible with any PMS symptoms. Zenstral had PMS has made the difference! I have none of the symptoms: headaches, cramps, irritability, mood swings or pain. This works! Thank you for this product! "

– Debbie Watts, North Carolina.

What is Zenstral PMS ™?

Zenstral PMS ™ is an innovative blend of natural substances that are scientifically proven to reduce PMS symptoms of premenstrual syndrome () and premenstrual dysphoric disorder (PMDD). Unlike other PMS treatments, Zenstral addresses both the physical and psychological symptoms of PMS / PMDD in a practical product without the risk of dangerous side effects.

The principles of evidence-based medicine, our physicians and pharmacologists formulated Zenstral PMS ™ after months of review of the results of university research studies worldwide. The result is a powerful nutraceutical that is as effective as other PMS means safer and. †

Who should Zenstral PMS ™?
Zenstral PMS ™ is recommended for women suffering from PMS symptoms fromgeneral

• cyclical mood symptoms of PMS including irritability, tension, depression
• lower back and joint pain with PMS
• Fluid retention associated with PMS
• Breast tenderness with PMS

What are the ingredients in Zenstral PMS ™?

Each capsule contains 20 mg Chaste Tree (.3% casticin), 200 mg magnesium (MgO) and 50 mg vitamin B6 (pyroxidine) ..

The chaste tree (VAC) compound is used in Zenstral casticin, a flavonoid from the chaste tree. This is the same substance in clinical studies, Chaste tree that show effective use. Almost all other products on the market to standardize agnuside, a terpene compound from the monk's pepper tree.

As works Zenstral PMS ™?

The natural compounds in Zenstral work on many of the biochemical mechanisms that contribute to PMS: †

Chaste Tree Extract (VAC): VAC acts on the hypothalamus-pituitary-adrenal (HPA axis), a series of complex interactions between the three hormone-producing Organs. It also reduces stress-induced prolactin levels by simulating the effects of dopamine in the brain (dopamine agonists) .6 In addition, VAC has been found to beta-endorphin opioid and to raise levels naturally occurring substances that reduce pain and create a sense of calm and well being.7, 8

Magnesium: Low concentrations of erythrocyte magnesium were correlated with symptoms of PMS.9 This is the reason for supplementation with magnesium and noted in a number of studies Magnesium supplementation resulted in women with PMS.

Vitamin B6: Also as pyroxidine, vitamin B6 has a positive effect on the level of the neurotransmitter such as serotonin, norepinephrine, histamine, dopamine and taurine.10

What is evidence-based medicine?

Evidence based medicine (EBM) requires examining a wide range of knowledge, such as meta-analysis, systematic reviews of existing research, randomized controlled trials, cohort studies, and other methods of inquiry to make decisions about patient care and treatment.

EBM is quickly becoming the new paradigm in health care, the place of the earlier authority-based model where the value of a medical treatment (and sometimes even their availability) was on the work of a limited number of Experts.

To learn more about evidence-based medicine, a non-profit organization called the Cochrane Collaboration (www.cochrane.org) is an excellent place to start.

What is a meta-analysis?

A meta-analysis includes the collection of data from many similar studies, then the analysis of pooled data for statistical significance.

What evidence was used in the formulation Zenstral PMS ™?

Below is a representative sample of scientific knowledge in the formulation Zenstral PMS ™ uses:

Vitex Agnus Castus Extract (VAC)

A recent double-blind, randomized, controlled study published in the British Medical Journal demonstrated a 52 percent reduction in PMS symptoms in women with dry extract of agnus castus fruit.11 similar results in another study in the Archives of Gynecology and Obstetrics.12 were published made treats

Another recent study found chaste tree extract to be as effective as fluoxetine in the treatment of PMDD, a severe form of PMS. The authors reported that 57.9 percent of patients responded to VAC extract in the treatment of this disease, and also found that VAC was more effective than fluoxetine in the treatment of physical Symptoms of the extract PMDD.13

German health authorities have approved the use of chaste tree for three gynecological disorders: menstrual cycle Irregularity, premenstrual syndrome (PMS) and mastodynia (chest pain) .14

Magnesium

A recent randomized, double-blind crossover study found that magnesium works synergistically with vitamin B6 to relieve symptoms of anxiety around with PMS.15

Vitamin B6

The British Medical Journal has a meta-analysis of vitamin B6 found in the treatment of PMS and that it was probably in the treatment of premenstrual symptoms of Use and premenstrual depression.16

Who should not Zenstral PMS ™?

Consult a physician before use if you are pregnant are nursing, taking the pill have a hormone-sensitive disease such as breast cancer or are under dopamine-related drugs.

How much should I take?

The typical dose is one capsule twice daily. Take Zenstral ™ every day of the month, not only if you have symptoms. It needs to reach and maintain therapeutic levels to work in the body.

When will it begin to work?

With daily use is Zenstral ™ therapeutic levels in your system takes only three minutes, four weeks ago, so you should feel relief by the second cycle. In contrast, take prescription antidepressants to work at least one month and not to the physical symptoms of PMS.

What are the possible Side effects?

No serious side effects for the ingredients in PMS ™ Zenstral been reported. Data from clinical trials, post-marketing surveillance Studies show spontaneous reporting systems, manufacturers and herbalist organizations that tolerate the compounds in Zenstral PMS ™ generally good, and that any side effects following VAC treatment are mild and reversible.17 Possible side effects include nausea, gastrointestinal complaints, headache, or pruritus.11, 12,13,15,16,17,18

Consult a doctor if you experience any of these side effects or use this product longer than six months. Stop taking and consult a doctor if an allergic Reaction occurs.

No drug interactions have been reported. However, since Zenstral's mode of action, consult with your doctor before use if you have Dopamine-related drugs.

What is the NPA TruLabel Program?

The Natural Products Association (NPA) program is the TruLabel industry's largest and most successful self-regulation program.

University Health Industries and other NPA members for voluntary monitoring of random tests of their products charged by independent laboratories. If a test shows no defects in the product quality or accuracy in labeling, NPA immediately notify the connected Company expected and that corrective action is taken. NPA revoke the membership of a company that does not meet the requirements.

What is Your warranty?

University Health Industries' products are backed by our 100% money-back guarantee for the initial appointment. If You are not completely satisfied for any reason, simply return your order, but within 30 days and we are in a full refund of the purchase price, minus Shipping and handling costs.

Who University Health Industries, Inc?

Every year, identify research laboratories around the world and test natural compounds with the potential to improve human health even more than 98% of these discoveries are never commercialized for the benefit of the public.

University Health Industries, Inc. (OTC: UVHI), in collaboration with universities worldwide natural products research with clinically proven efficacy identified, those with the greatest potential to improve human life, then they developed patented nutraceutical products for the treatment of chronic pain.

Our mission is to present the latest discoveries Natural products in clinical delivered to consumers are available in a patented pharmaceutical grade formulations with guaranteed quality and potency make.

UHI is a proud American company with offices and manufacturing facilities in Boca Raton, Florida. All our products are GMP-approved in the United States and to ensure order that they meet the standards you can trust the American public.

What other nutraceuticals UHI are from?

UHI is designed to introduce three new products in the coming weeks, each with the same quality and efficacy standards as Zenstral PMS ™:

• Arthroleve ULT ™ for bone and joint pain †
• Premium SAMe ULT ™ support for mood †
• Cold & Flu RMD ™ for immune system support and alleviate colds † from

References

1 Mortola J. Premenstrual syndrome-pathophysiologic considerations. N Engl J Med 1998; 338:256-7.

2 Chrousos GP, Torpy DJ, Gold PW. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Ann Intern Med 1998; 129:229-40.

3 Wyatt KM, Dimmock PW, O'Brien AM. Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database Syst Rev. 2002 (4): CD 001 396.

4 Wyatt KM, Dimmock PW, Ismail KM, Jones PW, O'Brien AM. The effectiveness of GnRHa with and without 'add-back "Therapy in the treatment of premenstrual syndrome: a meta-analysis. BJOG, 2004 Jun; 111 (6) :585-93.

5 Krasnik C, Montori VM, Guyatt GH, Heels-Ansdell D, Brusse JW; Medically Unexplained Syndromes Study Group. The effect of light therapy on depression associated with premenstrual dysphoric disorder. Am J Gynecol. Sep 2005, 193 (3 Pt 1) :658-61.

6 Merz PG, took Gorkow C, Schordter A, Rietbrock S, Sider C, Loew D, Dericks-Tan JSE, Taubert HD. The impact of special items Agnus castus extract (BP 109E1) on prolactin secretion in healthy male volunteers. Exp Clin Endocrinol Diabetes. 1996; 104:447-53.

7 Brugisser R, Burkard W, Simmen U, Schaffner W. Studies with an opioid-Rezeptorin Vitex agnus-castus L. Z Phytother. 1999; 20:140-58.

8 Samochowic L, R Glaesmer, J. Samochowic EifluBvon Monchspfeffer ON concentration of beta-endorphin in serum of female rats. Arztez natural remedies. 1998, 39:213-215.

9 Rosenstein DL, Elin RJ, Hosseini JM, et al. Magnesium measures across the menstrual cycle in premenstrual women. Biol Psychiatry. 1994; 35:557-61.

10 Schindler R, H Thoni, Classen HG. The role of magnesium in the development and therapy of benign muscle cramps. Combined in vivo / in vitro studies in rat phrenic nerve-diaphragm preparations. Apothekerverband submits research. 1998; 48:161-66.

11 Schellenberg, et al. Treatment for the premenstrual Syndrome with chaste tree fruit extract: prospective, randomized, placebo-controlled study. BMJ. 2001, 322; 134-7

12 Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with premenstrual syndrome (PMS). Arch Gynecol Obstet. 2000; 264:150-53.

13 Atmaca M, Selahattin K, E. Texcan fluoxetine versus dysphoric chaste tree extract in the treatment of premenstrual disorder. Human Psychopharmacol Clin Exp. 2003; 18:191-5.

14 Blumenthal M, Busse WR, Goldberg A, et al. The complete German Commission E monographs: therapeutic guide to herbal medicines. Austin TX. American Botanical Council. 1998, p1694.

15 De Souza M, Walker A, Robinson P, Bolland K. A synergistic effect of daily supplement for 1 month of 200mg magnesium plus 50mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of Women's Health & Gender-Based Medicine. 2000 Mar; 9 (2) 131-3.

16 K Wyatt, P Dimmock, P Jones, Shaughn O'brien PM. The efficacy of vitamin B-6 to write to the treatment of premenstrual syndrome: systemic. BMJ. 1999; 318:1375-81.

17 Daniele C, J Thompson, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005, 28 (4) :319-32.

18 Walker A, De Souza M, Vickers M, S Abeyasekera, Collins M, Trinca L. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of Women's Health. 1998 Nov; 7 (9) :1157-65.

19 Proctor M, Murphy P. Herbal dietary therapies for primary and secondary dysmenorrhoea (Cochrane Review). The Cochrane Library, Issue 2, 2002. Oxford: Update Software.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

About the Author

Dr. Jarret Morrow, MD, is the president of University Health Industries (OTC:UVHI). Dr. Morrow received his Doctor of Medicine from The University of Alberta in June 2001 and prior to that, received his Bachelor of Science with Specialization in Pharmacology with Distinction, also from The University of Alberta, in June 1997. Dr. Morrow has been a distinguished presenter at numerous scientific and medical conferences worldwide, generally involving various areas of psychiatry, including anxiety disorders and the physical impact of psychological stress, and has also co-authored numerous medical research publications generally involving similar subjects. Dr. Morrow also serves as the Company’s Chief Science Officer.

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